Endocrine Abstracts

Background: Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Thus, there is the necessity to find new therapeutic approaches. Thyroid hormones (TH) have a major impact on cardiac function and even appear to improve the outcome after acute ischemia/reperfusion and in chronic heart failure. Still, TH signaling within the heart is not yet completely understood.Aim: This project aims to investigate the influence of TH receptor al...

Ischemic heart disease (IHD) is one of the leading causes of death worldwide. TH have impact on cardiac function and even appear to improve outcome after acute ischemia/reperfusion and in chronic heart failure. This project aims to investigate the influence of TH receptor alpha (TRα) on IHD using specific mouse models to assess the contribution of canonical vs. non-canonical TH signaling. Mice underwent permanent ligation of the left descending coronary artery and were tr...

As thyroid hormones (TH) are essential for the normal heart function, a low TH state in ischemic cardiovascular events is often correlated to a poor prognosis. While clinical and experimental data suggests that TH intervention in acute myocardial infarction might be beneficial, a detailed insight in the mechanisms on TH action in IR injury or post infarct recovery of the heart is still lacking. In this study, we examined the effect of thyroid hormone pre- and postconditioning ...